Nobel Prize season begins every October as committees in Sweden and Norway name laureates in a variety of prizes in the sciences, literature and economics, as well as peace work. The announcements started on Monday this year with the awarding of the prize in Physiology or Medicine. They will continue until next Monday, when the Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel is announced.
The Nobel Prizes most years are presented to recipients in Stockholm and Oslo in December. Because of the coronavirus pandemic, the committees are changing their approaches. Some of the events in Stockholm will be canceled in favor of a digital ceremony for the Nobelists, and medals and diplomas are to be distributed to the recipients’ embassies and handed over in their home countries. Recipients may be invited to the award ceremony for 2021, if possible.
The Oslo ceremony for the peace prize will be smaller than in most years, with a limited audience.
The Nobel committee also announced another change last month: Each prize will rise to 10 million Swedish krona, 1 million more than in the previous year. That’s a hike in the prize value of about $112,000 in current exchange rates.
The Nobel Prize in Chemistry was jointly awarded on Wednesday to Emmanuelle Charpentier and Jennifer A. Doudna for their work on the development of Crispr-Cas9, a method for genome editing.The Nobel Committee’s selection of Emmanuelle Charpentier, now at the Max Planck Unit for the Science of Pathogens in Berlin, and Jennifer Doudna, at the University of California, Berkeley, puts an end to years of speculation about who would be recognized for their work developing the CRISPR–Cas9 gene-editing tools. The technology allows precise edits to the genome and has swept through laboratories worldwide since its inception in the 2010s. It has countless applications: researchers hope to use it to alter human genes to eliminate diseases; create hardier plants; wipe out pathogens and more.“The ability to cut DNA where you want has revolutionized the life sciences,” said Pernilla Wittung Stafshede, a biophysical chemist and member of the Nobel chemistry committee, at the prize announcement. “The ‘genetic scissors’ were discovered just eight years ago, but have already benefitted humankind greatly.”
Doudna and Charpentier and their colleagues did critical early work characterizing the system, but several other researchers have been cited — and recognized in other high-profile awards — as key contributors in the development of CRISPR. They include Feng Zhang at the Broad Institute of MIT and Harvard in Cambridge, Massachusetts, George Church at Harvard Medical School in Boston, Massachusetts, and biochemist Virginijus Siksnys at Vilnius University in Lithuania
Doudna was “really sound asleep” when her buzzing phone woke her and she took a call from a Nature reporter, who broke the news. “I grew up in a small town in Hawaii and I never in a 100 million years would have imagined this happening,” says Doudna. “I’m really stunned, I’m just completely in shock.”“I know so many wonderful scientists who will never receive this, for reasons that have nothing to do with the fact that they are wonderful scientists,” Doudna says. “I am really kind of humbled.”
Born from bacteria
CRISPR, short for clustered regularly interspaced short palindromic repeats, is a microbial ‘immune system’ that prokaryotes — bacteria and archaea — use to prevent infection by viruses called phages. At its core, the CRISPR system gives prokaryotes the ability to recognize precise genetic sequences that match a phage or other invaders and target these sequences for destruction using specialized enzymes.
Previous work had identified these enzymes, known as CRISPR-associated proteins (Cas), including one called Cas9. But Charpentier, working first at the University of Vienna and later at the Umeå Centre for Microbial Research in Sweden, identified another key component of the CRISPR system, an RNA molecule that is involved in recognizing phage sequences, in the bacterium Streptococcus pyogenes, which can cause disease in humans.
Charpentier reported the discovery in 2011 and that year struck up a collaboration with Doudna. In a landmark 2012 paper in Science1, the duo isolated the components of the CRISPR–Cas9 system, adapted them to function in the test tube and showed that the system could be programmed to cut specific sites in isolated DNA. Their programmable gene-editing system has inspired a gold rush of countless applicationsin medicine, agriculture and basic science— and work continues to tweak and improve CRISPR and to identify other gene-editing tools.
“We were hoping that we could really translate this into a technology for rewriting the genetic code of cells and organisms,” says Martin Jinek, a biochemist at the University of Zurich who was a postdoc in Doudna’s lab and a co-first author on the pivotal Science paper. “What we didn’t quite appreciate was how quickly the technology would be adopted by others in the field and then pushed forward.”
In less than a decade, researchers have used CRISPR-Cas9 to develop genome-edited crops, insects, genetic models and experimental human therapies. Clinical trials are under way to use the technique to treat sickle- cell -anaemia, hereditary blindness and cancer. Doudna, Charpentier and others in the field, have launched a generation of biotechnology companies aimed at developing the technique to achieve these goals.
In September, an international panel convened by leading US and UK scientific societies concluded again that the technology is not ready for use in human embryos that are destined for implantation. The work also sparked a fierce patent battle — chiefly between the Broad Institute and the University of California, Berkeley — that rumbles on to this day over who owns the lucrative intellectual property rights to CRISPR-Cas9 genome editing. It is always difficult to single out a discovery for a prize, says Francis Collins, a geneticist and head of the US National Institutes of Health in Bethesda, Maryland. “Virtually nothing comes out of nowhere,” he says. “It’s hard when you look at any discovery to decide who to pick.” But one unique aspect of CRISPR-Cas9 genome editing has been the ease and versatility of the technique, he adds. “CRISPR-Cas made this so much more readily acceptable,” says Collins. “There is no molecular biology laboratory that I know of that hasn’t started to work with CRISPR-Cas.” This is the first time a nobel science prize is given to an only-women team and it’d be say we’re all exhilarated about it. We hope to see more women coming up with amazing discoveries and get recognised for their work. These achievements by amazing women act as a motivation to women in every nook and corner of the world, to go out there and change the world with their intellect. It’s beautiful to see the work getting recognised and appreciated throughout the world. Let’s keep the nobels coming.